Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats
Table 1
(a) Hepato-antioxidant status of hydroethanolic extract of C. afer on STZ-induced diabetic rats
SOD (U/min/mg of protein)
CAT (U/min/mg of protein)
GSH (mol/mg of protein)
MDA (mol/mg of protein)
Control
10.69 ± 1.63
1.73 ± 1.22
28.09 ± 9.93
1.69 ± 0.35
Diabetic control
22.91 ± 1.11
9.99 ± 5.11
44.12 ±14.73
7.64 ± 0.26
DHE 250 mg/kg
16.54 ± 1.85
5.91 ± 4.36
32.65 ±11.37
2.92 ± 0.22
DHE 500 mg/Kg
15.14 ± 1.42
3.20 ± 3.02
28.53 ± 7.23
1.59 ± 0.25
DHE 1000 mg/kg
14.91 ± 2.91
2.79 ± 1.48
24.56 ± 2.53
1.09 ± 0.72
Met 250 mg/Kg
14.17 ± 3.34
2.28 ± 1.67
23.24 ± 4.81
1.35 ± 0.15
(b) Cardio-antioxidant status of hydroethanolic extract of C. afer on STZ-induced diabetic rats
SOD (U/min/mg of protein)
CAT (U/min/mg of protein)
GSH (mol/mg of protein
MDA (mol/mg de protein)
Control
22.89 ± 4.10
372.16±42.56
237.94±5.52
3.8 ± 0.36
Diabetic Control
108.13±14.39
983.24±65.17
260.00±3.47
6.49 ± 0.58
DHE 250 mg/kg
40.45 ± 0.81
531.91±41.55
249.71±17.87
3.05 ± 2.85
DHE 500 mg/Kg
37.96 ± 7.41
497.80±27.52
240.15 ± 4.37
2.60 ± 0.25
DHE 1000mg/kg
23.26 ± 6.24
475.82±68.50
225.44±21.36
1.74 ± 0.11
Met 250 mg/Kg
22.66 ± 6.58
381.73±37.67
225.29±22.17
2.14 ± 1.20
(c) Reno-antioxidant status of hydroethanolic extract of C. afer on STZ-induced diabetic rats
SOD(U/min/mg of protein)
CAT (U/min/mg of protein)
GSH (mol/mg of protein)
MDA (mol/mg of protein)
Control
11.66 ± 2.13
48.12 ±2.36
133.97± 5.46
4.68 ± 1.89
Diabetic Control
28.85 ± 2.95
186.67±78.46
64.71± 10.59
6.86 ± 0.33
DHE 250 mg/kg
25.45 ± 2.93
98.38 ± 4.77
69.85 ± 3.33
4.65 ± 0.46
DHE 500 mg/Kg
20.16 ± 1.79
83.38 ± 2.93
87.65 ± 7.04
3.94 ± 0.16
DHE 1000mg/kg
13.95 ± 6.23
50.96 ± 4.77
125.00±2.89
3.09 ± 0.59
Met 250 mg/Kg
12.64 ± 1.28
50.62 ± 9.04
100.74 ±3.33
3.08 ± 0.03
DHE: diabetic treated with hydroethanolic extract of C. afer; Met: metformin. SOD: superoxide dismutase, CAT: catalase, GSH: reduced glutathione, MDA: Malondialdehyde. Each value represents mean S.E.M. (n=6). Means with different letters (a, b, c, and d) within a column are significantly different from each other at < 0.05.
