Whole Body Vibration Retards Progression of Atherosclerosis via Insulin-Like Growth Factor 1 in Apolipoprotein E-Deficient Mice

Figure 4

Effect of WBV for 12 weeks on the IGF-1-ERK sisgnaling pathway. (a) Serum IGF-1 levels were detected by ELISA after 12 weeks of vibration. (b) Q-PCR analysis of mRNA levels of IGF-1R in mice aorta. (c) Western blots analysis of IGF-1R and p-IGF-1R in mice aorta. (d) Quantification of the western blot analysis of p-IGF-1R expression in the aorta. (e) Protein expression of ERK and p-ERK in aortas after vibration for 12 weeks. (f) Western blot analysis of ERK and p-ERK proteins in ApoE^−/− mice. The expression of these proteins was quantified as relative expression after normalization to GAPDH expression. Values are means ± SEM, , and versus control group.

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