Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Table 3

Drugs used by patients with sIBM, duration of treatment, side effects, and clinical and laboratory changes related to the treatment.

Case	Drug	Duration	Side effects	Clinical and laboratory changes
1	AZAT 150 mg/day	6 months	Chills + prostration	No
	PRED 60 mg/day	8 years	No	No
	PRED 60 mg 8/8 hours	90 days	Anasarca	No
	Mofetil	3 months	Diarrhea + consumptive syndrome	No
	MTX 20 mg/week	3 years	No	No
2	PRED 60 mg/day	9 days	Anasarca	No
3	IVIG 400 mg/kg	PT 2 days (for 2x)	No	No
	Abatacept	10 doses	No	Light motor improvement NS
	Leflunomide 20 mg/day	3 years	No	No
	PRED 30 mg/day	6 years	No	No
	Cyclophosphamide	1 year	No	No
	AZAT until 250 mg/day	1 year	Leukopenia	No
	Cyclosporine	2x pulse therapy	No	No
4	Deflazacort 45 mg/day	1 month	Weakness worsens	No
	Deflazacort 30 mg/day	4 months	No	No
5	MTX 7,5 mg/week	4 years	No	No
6	PRED 60 mg/day	1 year	No	No
	AZAT 250 mg/day + PRED 20 mg/day	2 months	No	No
	MP 1 gram	PT for 2 days	No	Light motor improvement NS
8	AZAT		Pancytopenia	No
	Cyclosporine		Incoercible vomit	No
	PRED 40 mg/day	3 years	Drug Cushing’s syndrome	No
	MP 1 grama	PT for 2 days	No	Partial improvement of dysphagia
	MTX	1 year	Gastric intolerance	No
10	AZAT 150 mg/day	1.5 years	No	No
	MTX 20 mg/week + PRED 60 mg/day	2 years	No	No
	Rituximab	1 cycle	No	No
11	MP 1 gram	PT 5 days	No	No
	PRED 40 mg/day	6 months	No	Reduction CK/no improvement
	MTX + AZAT	4 years	No	Reduction CK/no improvement
12	IVIG 400 mg/kg	2 years	No	No
13	PRED (maximum dose 80 mg/day)	8 years	Edema + weight gain	No
	MP 1 grama + IVIG 400 mg/kg	PT for 2 days/each	No	Light motor improvement NS
	AZAT	1.5 years	No	No
14	MTX	1 month	Gastric intolerance	No
16	MTX	1 year	No	No
	Coenzyme-Q10	15 months	No	No
	Riluzole	15 months	No	No
17	PRED 20 mg/day	6 months	No	No
18	PRED 60 mg/day + folic acid 5 mg/day	9 months	Edema + weight gain	Light motor improvement NS

AZAT = azathioprine. PRED = prednisone. MTX = methotrexate. IVIG = intravenous human immunoglobulin. MP = methylprednisolone. CK = creatine phosphokinase. NS = nonsustained. PT = pulse therapy.