Circulating CD3+CD4+CD161+ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma
Table 3
Multivariate analyses of risk factors for the occurrence of mucositis, infection before engraftment, and CMV reactivation.
Variable
Mucositis (≥grade 3)
Infection before engraftment (CDI + MDI)
CMV reactivation
RR (95% CI)
RR (95% CI)
RR (95% CI)
CD3+CD4+CD161+ cells (%) (≤3.72 versus >3.72)
0.19 (0.04–0.73)
0.020
0.20 (0.06–0.73)
0.014
0.25 (0.09–0.72)
0.010
Sex (female versus male)
6.39 (1.74–29.71)
0.009
6.87 (2.05–23.04)
0.020
-
-
BMI (kg/m2), continuous
0.82 (0.64–1.03)
0.094
0.87 (0.71–1.08)
0.213
0.95 (0.78–1.16)
0.595
GFR (ml/min/1.73 m2), continuous
0.98 (0.97–1.00)
0.020
1.00 (0.98–1.01)
0.502
-
-
Pulmonary
None/mild
-
-
1
-
-
Moderate
-
-
1.29 (0.40–4.12)
0.671
-
-
Severe
-
-
5.54 (1.10–27.85)
0.038
-
-
BMI, body mass index; CDI, clinically defined infection; CI, confidence interval; CMV, cytomegalovirus; GFR, glomerular filtration rate; MDI, microbially defined infection; RR, relative risk. Modification of diet in renal disease (MDRD) GFR was used.
