Review Article

Theory of Mind after Severe Acquired Brain Injury: Clues for Interpretation

Table 2

Summary of studies that investigated the relationship between ToM and cognitive and emotional functions.

Published reports Characteristics of the patient groupAssociation with cognitive variablesAssociation with emotional and affective variables

Apperly et al. [32]12 ABI (unspecified severity)
3 HCs
Executive functionNot investigated

Bara et al. [38]13 sABI
13 HCs
Comprehension of irony, pragmatic communication (n.s.)Not investigated

Bibby and McDonald [22]15 sTBI
15 HCs
Working memor (significant relationship only with non-verbal and second-order
verbal ToM performance); Implicit languag
Not investigated

Bivona et al. [28]28 sTBI
28 HCs
Executive functionEmotional responsiveness, Empathy (n.s.)
Apath, Self-awarenes

Bivona et al. [29]20 sTBI
20 HCs
Executive functions (n.s.)Alexithymia (n.s.)

Bosco et al. [39]30 moderate-to-severe TBI
30 HCs
Executive functions (n.s.)Not investigated

Channon and Crawford [31]7 ABI, 16 vascular, 5 cancer, 2 abscess, 1 sclerosis (unspecified severity)
60 HCs
Executive functionNot investigated

Channon and Crawford [40]10 sABI, 10 vascular (unspecified severity)
20 HCs
Comprehension of irony;
Comprehension of social context and awkward situatio
Not investigated

Channon et al. [41]19 sABI
19 HCs
Comprehension of sarcasNot investigated

De Sousa et al. [37]21 sTBI
22 HCs
Not investigatedReduced psychophysiological reacti- vity during emotional stimulatio

Grattan and Eslinger [42]50 ABI, 27 infarction, 5 surgical resection of tumor, 8 aneurysm rupture, 10 closed head injury (unspecified severity)Not investigatedApath

Griffin et al. [43]11 vascular ABI (unspecified severity)
20 HCs
Executive functions, mentalistic attribution ability, humour rating (n.s.)Emotion perception (n.s.)

Havet-Thomassin et al. [44]17 sTBI
17 HCs
Executive functions (n.s.)Not investigated

Henry et al. [33]16 mild-to-moderate TBI
17 HCs
Executive functionAbility to recognise facial expressions related to emotions (n.s.)

Honan et al. [45]25 sTBI
25 HCs
High Working MemorNot investigated

Martin and McDonald [46]16 TBI (unspecified severity)
16 HCs
Inferential reasonin; Irony comprehension (n.s.)Not investigated

Martin and McDonald [47]21 ABI (unspecified severity)
21 HCs
Executive functions; Irony comprehension (n.s.)Not investigated

McDonald and Flanagan [48]34 sTBI
34 HCs
Detection of irony and lies (n.s.)Ability to recognise emotional expressions of faces and voices (n.s.)

McDonald and Pearce [34]9 ABI, 1 vascular (unspecified severity)
20 HCs
Executive functions (data applicable only to a sub-samplAbility to recognise facial expressions related to emotion

McDonald et al [49]31 sTBI
25 HCs
Difficulty understanding insincere comments such as sarcasEmotion perception (n.s.)

Milders et al. [50]17 moderate-to-severe TBI
17 HCs
Cognitive flexibility; Understanding Intentions and Social Situations (n.s.)Ability to recognize emotional expressions in faces and voices (n.s.)

Milders et al. [51]33 moderate-to-severe TBI
36 orthopedic control patients
Executive functionNot investigated

Milders et al. [26]33 mild-to-severe TBI
34 orthopedic control patients
Cognitive flexibility (n.s.)Ability to recognise emotional expressions in faces and voices (n.s.)

Muller et al. [27]15 sTBI
15 orthopedic control patients
Executive functions (n.s.)Not investigated

Neumann and coll. [52]60 moderate-to-severe TBI
60 orthopedic control patients
Not investigatedAlexithymi

Njomboro et al. [53]49 ABI, 24 cerebrovascular accident, 14 head injury, 5 anoxia, 6 herpes simplex encephalitis
49 HCs
Executive functions (n.s.)Apathy and perception of facial expressions of emotion (n. s.)

Rowe et al. [54]31 ABI (unspecified severity)
31 HCs
Executive functions (n.s.)Not investigated

Shamay-Tsoory et al. [35]33 ABI, 6 vascular, 5 meningioma
18 HCs (unspecified severity)
Not investigatedEmotional variables of the stimul

Shaw et al. [25]19 ABI (unspecified severity)
19 HCs
Not investigatedAbility to recognise and evaluate facial expressions related to emotions (n.s.)

Spikman et al. [55]28 moderate-to-severe ABI
33 HCs
Executive functions (n.s.)Relationship between ToM and discrimination of emotion

Turkstra et al. [56]58 moderate-to-severe TBI
66 HCs
Working MemorNot investigated

Williams and Wood (2009)64 sTBI
64 HCs
Not investigatedRelationship between reduced empathy and alexithymi; 64 % of TBI patients reported low emotional empathy

sABI: patients with severe acquired brain injury.
sTBI: patients with severe traumatic brain injury.
HCs: healthy control subjects.
n.s.: non-statistically significant relationship.
towards statistically significant relationship.
significant relationship.