Blockade of RBP-J-Mediated Notch Signaling Pathway Exacerbates Cardiac Remodeling after Infarction by Increasing Apoptosis in Mice

Figure 1

Knockout of the RBP-J gene. (a) Expression level of the RBP-J protein by western blot analysis. Significant differences were observed between Myh6-RBP- mice and RBP- mice (, ). (b&c) mRNA expression of Hes1 and Hey1 by real time PCR. Significant differences in the expression of Hes1 and Hey1 mRNA were observed in the myocardium of Myh6-RBP- mice and RBP- mice (, ). (d) Kaplan-Meier analysis showed a significantly lower survival rate in Myh6-RBP--MI mice than in RBP--MI mice (log-rank: ).

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