Research Article

Utility of Borrelia burgdorferi sensu stricto C6 Peptide for Serologic Confirmation of Erythema-Free Ixodid Tick-Borne Borrelioses in Russia

Figure 1

(a) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM patients (except serum samples from patients with multiple EM skin lesions). The samples were taken prior to treatment (N = 186) and on days 7-14 (N = 178) and ≥15 (N = 119) after disease onset. Statistically significant differences (Fisher’s exact test, p < 0.05) were observed for comparison of pairs: C6 IgG versus C6 IgM, OspC IgM, or VlsE IgM prior to treatment and at different times postbaseline. These values are denoted as
(b) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM patients coinfected with HGA agent (except serum samples from patients with multiple EM skin lesions). The samples were taken prior to treatment (N = 69) and on days 7-14 (N = 69) and ≥15 (N = 37) after disease onset. Statistically significant differences (Fisher’s exact test, p < 0.05) were observed for comparison of pairs: C6 IgG versus C6 IgM, OspC IgM, or VlsE IgM prior to treatment and at different times of observation. These values are denoted as
(c) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM patients coinfected with TBE virus. The samples were taken prior to treatment (N = 17) and on days 7-14 (N = 17) and ≥15 (N = 9) after disease onset. Statistically significant differences were not observed