Research Article

Utility of Borrelia burgdorferi sensu stricto C6 Peptide for Serologic Confirmation of Erythema-Free Ixodid Tick-Borne Borrelioses in Russia

Figure 2

(a) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM-free patients. The samples were taken prior to treatment (N = 31) and on days 7-14 (N = 29) and ≥15 (N = 21) after disease onset. Statistically significant differences (Fisher’s exact test, p < 0.05) were observed for comparison of pairs: C6 IgM/IgG versus C6 IgG and OspC IgM at days 7-14 postbaseline; C6 IgM/IgG+VlsE IgM versus C6 IgG and OspC IgM at days 7-14 postbaseline. These values are denoted as
(b) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM-free patients coinfected with HGA agent. The samples were taken prior to treatment (N = 40) and on days 7-14 (N = 43) and ≥15 (N = 23) after disease onset. Statistically significant differences (Fisher’s exact test, p < 0.05) were observed for comparison of pairs: C6 IgM/IgG+VlsE IgM versus C6 IgM/IgG, C6 IgG, C6 IgM, or OspC IgM at days 7-14 postbaseline. These values are denoted as
(c) Sensitivity of PHOSPHAN tests detecting IgM and IgG to Borrelia antigens in sera from EM-free patients coinfected with TBE virus. The samples were taken prior to treatment (N = 27) and on days 7-14 (N = 26) and ≥15 (N = 22) after disease onset. Statistically significant differences were not observed