Utility of Borrelia burgdorferi sensu stricto C6 Peptide for Serologic Confirmation of Erythema-Free Ixodid Tick-Borne Borrelioses in Russia
Table 1
Clinical and epidemiological characteristics of ITBB patients (N = 442) enrolled in the research.
Characteristic
EM Patients
EMF Patients
Monoinfection (N = 220)
Coinfection with HGA (N = 89)
Coinfection with TBE (N = 18)
Monoinfection (N = 38)
Coinfection with HGA (N = 44)
Coinfection with TBE (N = 33)
Median (range) age (yr)
58 (15-87)
55 (18-84)
60 (25-80)
53 (16-86)
54 (15-81)
53 (18-79)
Sex
No. (%) male
102 (46.4)
48 (53.9)
8 (44.4)
18 (47.4)
31 (70.5)
15 (45.5)
No. (%) female
118 (53.6)
41 (46.1)
10 (55.6)
20 (52.6)
13 (29.5)
18 (54.5)
Tick bite history
No. (%) of patients
216 (98.2)
84 (94.4)
18 (100)
34 (89.5)
43 (97.7)
30 (90.9)
Median (range) time from tick bite to disease (days)
11 (1-65)
11 (2-34)
10 (1-29)
14 (1-50)
14 (2-59)
15 (1-50)
Median (range) time from disease to study entry (days)
5 (1-61)
7 (1-48)
3 (1-25)
4 (1-63)
4 (1-62)
4 (1-49)
Disease severity
No. (%) mild
178 (80.9)
64 (71.9)
15 (83.3)
5 (13.2)
7 (15.9)
11 (33.3)
No. (%) moderate
42 (19.1)
25 (28.1)
3 (16.7)
33 (86.8)
37 (84.1)
22 (66.7)
No. (%) of patients with positive Borrelia PCR
13/93 (13.9)
26/38 (68.4)
3/11 (27.3)
6/9 (66.7)
12/20 (60.0)
5/17 (29.4)
including no. of patients with
B. afzelii
7
1
1
0
2
0
B. garinii
4
16
2
6
7
5
B. afzelii + B. garinii
0
5
0
0
2
0
B. burgdorferi sensu lato
2
4
0
0
1
0
No. (%) of patients with positive VlsE C6 antibody response at study entry
C6 IgM/IgG
94 (42.7)
65 (73.0)
7 (38.9)
18 (47.4)
19 (43.2)
24 (72.7)
C6-IgM
36 (16.4)
34 (38.2)
4 (22.2)
11 (28.9)
11 (25.0)
8 (24.2)
C6-IgG
80 (36.4)
56 (62.9)
5 (27.8)
8 (21.1)
12 (27.3)
19 (57.6)
EM = erythema migrans; EMF = erythema migrans-free. Data were determined by the hospital’s medical laboratory. Disease severity was determined as a function of a number and intensity of the associated symptoms. Number of patients tested positive (numerator) out of total number of patients tested by Borrelia PCR (denominator). Results of B. burgdorferi C6 peptide based PHOSPHAN are represented. Statistically significant differences (Fisher’s exact test, p < 0.05) were observed for comparison of median time from tick bite to disease in EM patients (monoinfection) versus any of the EM-free patients.
