Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest
Results of MTT (b) and colony formation assay (c,d). Both assays showed that combination of caffeine and TMZ exerted enhanced antiproliferative effect in comparison with TMZ alone. Furthermore, pretreatment of caffeine produced additional benefits only when it was followed by combined treatment but not TMZ alone. Images from bright field demonstrated the same trend (a). , #, and & represent for p < 0.05 when compared to control, TMZ, and TC, respectively.
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