Review Article
Weaning from Mechanical Ventilation in ARDS: Aspects to Think about for Better Understanding, Evaluation, and Management
Table 1
Potential methods for predicting weaning in ARDS.
| Potential Method | Advantages | Disadvantages |
| Esophageal pressure[42, 43] | Pressure measurements with spontaneous ventilation Quantification of pulmonary swings Help in the visualization of asynchrony | Difficulty in positioning the catheter and its accuracy for measuring esophageal pressure Minimally Invasive |
| P0.1[44, 45] | Evaluation of ventilatory drive | Failure of previous studies as a predictor of general weaning failure |
| Lung ultrasound [46ā48] | Non-invasive Quantification of aeration and collapse during weaning | Operator dependent Skin lesions may make it impossible to perform the test |
| Echocardiography[49] | Evaluation of the heart-lung interaction Measures left and right ventricular function | Same as above Cardiac images are difficult to visualize in some patients |
| Asynchrony[36, 50] | Quantification of asynchrony and better adjustment of parameters and modes of mechanical ventilation during weaning | Automatic devices that are validated for clinical use are missing |
| EIT[51ā54] | Non-invasive and radiation-free Real-time visualization of aeration and collapsed lung and swings during weaning Evaluation of pulmonary perfusion | Artifacts caused by changes in thoracic shape, providing three-dimensional absolute/relative images with better resolution |
| Biomarkers[55] | Evaluation of VILI and P-SILI worsening during mechanical ventilation weaning | Influence by extrapulmonary inflammatory response |
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EIT: Electrical Impedance Tomography; VILI: Ventilator-Induced Lung Injury; P-SILI: patient self-inflicted lung injury.
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