The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Inflammation in Rheumatic Patients with Arthritis

Table 2

The correlation between clinical variables in patients with rheumatic disease and the proportion of myeloid derived suppressor cells, as well as their subsets.

Correlation Analysis		MDSC		M-MDSC		G-MDSC
		r	p	r	p	r	p
Rheumatoid Arthritis	Age (years)	-0.255	0.165	-0.239	0.195	-0.145	0.436
	Disease Duration (years)	0.007	0.972	0.052	0.781	-0.093	0.621
	ESR (mm/h)	0.265	0.150	0.322	0.077	0.081	0.665
	CRP (mg/L)	0.379	0.036	0.594	0.000	-0.095	0.611
	Total Joint Pain (scores)	0.529	0.002	0.766	0.000	0.142	0.446
	Swollen Joint Counts (n)	0.305	0.095	0.371	0.040	0.164	0.379
	HAQ (scores)	-0.003	0.987	0.160	0.390	0.066	0.722
	DAS28 (scores)	0.481	0.006	0.749	0.000	0.047	0.801
	IgM RF (IU/ml)	0.140	0.453	0.272	0.139	0.015	0.936
	ACPA (U/ml)	0.475	0.007	0.668	0.000	0.000	1.000
Ankylosing Spondylitis	Age (years)	-0.154	0.506	-0.211	0.359	-0.142	0.538
	Disease Duration (years)	-0.217	0.345	-0.214	0.352	-0.330	0.144
	ESR (mm/h)	0.087	0.709	-0.145	0.529	0.046	0.844
	CRP (mg/L)	0.494	0.023	0.801	0.000	0.043	0.854
	Total Joint Pain (scores)	0.707	0.000	0.799	0.000	-0.065	0.780
	ASDAS (scores)	0.596	0.004	0.908	0.000	0.042	0.858
	BASFI (scores)	0.228	0.320	0.251	0.273	-0.151	0.512
Osteoarthritis	Age (years)	0.051	0.863	0.055	0.852	-0.256	0.376
	Disease Duration (years)	0.073	0.805	-0.068	0.817	-0.276	0.34
	ESR (mm/h)	0.037	0.899	0.037$	0.900	-0.165$	0.573
	CRP (mg/L)	0.877	0.000	0.746$	0.002	0.408$	0.148
	Total Joint Pain (scores)	0.813	0.000	0.844	0.000	0.387	0.171
	Swollen Joint Counts (n)	0.330	0.250	0.590	0.026	0.186	0.525
Systemic Lupus Erythematosus With Arthritis	Age (years)	0.061$	0.858	-0.460	0.154	0.234$	0.489
	Disease Duration (years)	0.133	0.697	0.078	0.820	0.357	0.281
	ESR (mm/h)	0.173	0.611	0.378	0.252	-0.342	0.304
	CRP (mg/L)	0.555	0.077	0.855	0.001	-0.309	0.355
	Total Joint Pain (scores)	0.761$	0.007	0.934	0.000	0.101$	0.768
	Swollen Joint Counts (n)	0.551	0.079	0.918	0.000	-0.217	0.522
	SLEDAI (scores)	0.139$	0.683	0.161	0.636	0.607$	0.048
	ANA (U/ml)	-0.184$	0.589	0.000	1.000	0.335$	0.315
	Anti-dsDNA (U/ml)	0.203$	0.549	0.182	0.593	0.622$	0.041
	C3 (g/L)	0.229$	0.497	-0.328	0.352	-0.112$	0.743
Systemic Lupus Erythematosus Without Arthritis	Age (years)	0.059	0.847	-0.039	0.900	0.033	0.915
	Disease Duration (years)	-0.155	0.613	-0.077	0.801	0.109	0.722
	ESR (mm/h)	0.252	0.405	0.163	0.596	-0.072	0.816
	CRP (mg/L)	0.171	0.577	0.489	0.090	-0.149	0.628
	SLEDAI (scores)	0.038$	0.901	-0.196$	0.522	0.054	0.861
	ANA (U/ml)	0.219$	0.471	-0.067$	0.828	0.096	0.754
	Anti-dsDNA (U/ml)	-0.315$	0.295	-0.244$	0.421	-0.077	0.802
	C3 (g/L)	-0.433$	0.139	-0.580$	0.038	-0.432	0.141
Gout	Age (years)	-0.770	0.015	-0.683	0.042	-0.169$	0.665
	Disease Duration (years)	-0.218	0.574	-0.200	0.606	0.051$	0.897
	ESR (mm/h)	0.151	0.699	0.433	0.244	0.235$	0.543
	CRP (mg/L)	0.762	0.017	0.883	0.002	0.833	0.005
	Total Joint Pain (scores)	0.795	0.010	0.911	0.001	0.868$	0.002
	Swollen Joint Counts (n)	0.712	0.031	0.878	0.002	0.833	0.005
	SUA (μmol/L)	-0.151	0.699	-0.183	0.637	0.082$	0.833
Hyperuricemia	Age (years)	0.077$	0.833	-0.123	0.736	0.330$	0.351
	Disease Duration (years)	0.091	0.803	0.018	0.960	0.049	0.894
	ESR (mm/h)	-0.395$	0.259	-0.326	0.358	-0.170$	0.640
	CRP (mg/L)	0.430	0.214	0.159	0.661	0.543	0.105
	SUA (μmol/L)	-0.231$	0.522	-0.275	0.441	0.213$	0.554

Note: ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; HAQ, health assessment questionnaire; DAS28, disease activity score in 28 joints; RF, rheumatoid factor; ACPA, anti-citrullinated protein antibody; ASDAS, ankylosing spondylitis disease activity score; BASFI, bath ankylosing spondylitis functional index; SLEDAI, systemic lupus erythematosus disease activity index; ANA, antinuclear antibody; Anti-dsDNA, anti-double stranded DNA antibody; C3, complement C3; SUA, serum uric acid; MDSC, myeloid derived suppressor cell; M-MDSC, monocytic MDSC; G-MDSC, granulocytic MDSC; Total Joint Pain was assessed on a visual analog scale (0-10 cm); r, all showed by Spearman’s rank correlation coefficient, except when marked with $ (Pearson’s correlation coefficient);. p<0.05, p<0.01, and p<0.001.