A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China

Table 3

Meta-analysis of clinical manifestations of brucellosis by age category.

Manifestation	Age category						All studies
	Children		Adults		All ages
General		% [95% CI]		% [95% CI]		% [95% CI]		% [95% CI]
Fever	10	92 ;	17	99 ;	41	83 [80; 87]	68	87 [85; 90]
Fatigue	7	68 ;	14	64 ;	34	62 [57; 67]	55	63 [59; 67]
Chills	3	26 ;	5	53 ; 79]	4	37 [33; 42]	12	43 [33; 55]
Sweats	8	60 ;	16	57 [48; 68]	39	54 [49; 59]	63	55 [51; 60]
Arthralgia	9	52 ;	17	61 [52; 70]	40	63 [59; 68]	66	62 [58; 65]
Headache	4	8 ;	10	29 [19; 42]	27	21 [18; 25]	41	21 [18; 25]
Muscle pain	2	31 ;	5	76 [60; 95]	20	53 [47; 59]	27	56 [51; 62]
Nausea/vomiting	6	27 ;	8	26 [15; 45]	17	25 [19; 34]	31	26 [21; 33]
Rash	3	13 ;	3	7 [3; 19]	9	5 [3; 11]	15	7 [4; 11]
Weight loss	0	-	4	26 [14; 47]	5	32 [17; 61]	9	29 [17; 48]
Skin petechia	3	8 ;	2	18 [10; 32]	9	5 [3; 8]	14	7 [4; 10]
Abdominal pain	2	6 ;	3	6 [3; 14]	3	8 [4; 16]	8	8 [5; 11]
Chest pain	0	-	2	7 [3; 17]	1	5 [3; 10]	3	6 [3; 10]
Cough	5	12 ;	4	19 [12; 29]	5	10 [8; 14]	14	12 [10; 15]
Hepatomegaly	7	28 ;	7	23 [13; 40]	23	13 [10; 17]	37	16 [13; 20]
Splenomegaly	7	35 ;	10	29 [22; 39]	23	21 [16; 27]	40	24 [20; 29]
Lymphadenectasis	7	38 ;	7	32 [22; 48]	27	16 [12; 21]	41	19 [15; 25]
Hepatitis	8	48 ;	15	60 [52; 69]	24	38 [30; 49]	47	45 [38; 54]
Neurological	4	8 ;	3	8 [2; 36]	14	4 [2; 9]	21	5 [3; 10]
Cardiac	3	19 ;	2	5 [1; 19]	12	9 [6; 14]	17	9 [6; 16]
Hemophagocytic syndrome	0	-	0	-	4	6 [2; 23]	4	6 [2; 23]
Respiratory	5	26 ;	3	11 [6; 20]	8	9 [4; 23]	16	13 [7; 21]
Orchitis/; epididymitis	1	67 ;	7	6 [3; 12]	34	9 [7; 12]	42	9 [7; 12]
Osteoarthritis	2	16 ;	4	22 [9; 52]	11	23 [17; 31]	17	22 [17; 29]