Expression of miR-652-3p and Effect on Apoptosis and Drug Sensitivity in Pediatric Acute Lymphoblastic Leukemia

Figure 1

Expression pattern of miR-652-3p in plasma and bone marrow (BM) samples. (a) Hierarchical clustering of three healthy controls (No. 1-3), three pediatric patients with acute lymphoblastic leukemia (ALL) (No. 4-6) at their new diagnosis (ND) or complete remission (CR), and another three pediatric patients with ALL (No. 7-9) at relapse (RE), based on the expression profile of circulating miRNAs, as examined by qRT-PCR-based TaqMan low-density miRNA arrays. The expression pattern of miR-652-3p is indicated by a blue arrow. (b) BM samples were obtained from three pediatric patients with ALL apart from the ones in (a) at ND, CR, and RE. The changes in the expression of miR-652-3p were detected by qPCR. (c) Sample size in (b) was enlarged to 86 patients, and the expression of miR-652-3p in BM was analyzed at ND and CR.

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