Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

<div>FT improves survival of mice infected with P. aeruginosa antibiotic-resistant clinical isolates of exoU+ (1840) and exoS+(KB6) genotypes. (a) mice infected with clinical isolate 1840, 6.45x106 CFU/animal; (b) mice infected with clinical isolate 1840, 3.2x106 CFU/animal; (c) mice infected with clinical isolate KB6, 2.2x 107 CFU/animal; (d) mice infected with clinical isolate KB6, 1.1x107 CFU/animal. Infected animals were treated with 50 mg/kg of FT per os immediately after infection for 4 days twice a day. Black line, control; dotted line, FT-treated mice.</div>

BioMed Research International

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Figure 1

Figure 1: Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

Figure 1 | Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice 