Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

<div>Combined prophylaxis-therapy treatment with FT improves survival of mice infected with P. aeruginosa antibiotic-resistant clinical isolates of exoU+ (1840) and exoS+(KB6) genotypes. (a) mice infected with clinical isolate 1840, 7.0х106 CFU/animal; (b) mice infected with clinical isolate 1840, 3.5х106 CFU /animal; (c) mice infected with clinical isolate KB6, 1.75х107 CFU/animal; (d) mice infected with clinical isolate KB6, 8х106 CFU/animal. Mice were treated with 100 mg/kg of FT per os once a day for 2 days before infection and with 50 mg/kg of FT twice a day for 4 days starting immediately after infection.</div>

BioMed Research International

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Figure 3: Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice

Figure 3 | Small Molecule Inhibitor of Type Three Secretion System Belonging to a Class 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-ones Improves Survival and Decreases Bacterial Loads in an Airway Pseudomonas aeruginosa Infection in Mice 