Research Article
Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of Reserpine-Induced Depression
Figure 2
Effect of Gyejibokryeong-hwan (GBH) on development of reserpine-induced depression in mice. Mice underwent oral treatment with vehicle (PBS), GBH (50, 100, 300, or 500 mg·kg−1), fluoxetine (FXT, 20 mg·kg−1), or amitriptyline (AMT, 30 mg·kg−1) once per day for 10 days. (a) Schematic showing reserpine treatment, oral administration schedule, and behavioral testing timeline. (b) Body weight and (c) food intake were measured on days 1, 5, and 10. Data are presented as the mean ± standard deviation (SD) (n = 6, one-way ANOVA; < 0.05, < 0.001 versus normal; p < 0.05, p < 0.01, p < 0.001 versus control).
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