Clinically Correlated MicroRNAs in the Diagnosis of Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Table 2
Subgroup analyses for the selected studies.
Subgroups
No
SEN [95CI]
SPE [95CI]
PLR[95CI]
NLR [95CI]
DOR[95CI]
AUC [95CI]
MiR profiling
single
26
0.770.71-0.82]
0.800.77-0.84]
3.93.3-4.7]
0.280.22-0.36]
1410-20]
0.860.82-0.88]
multiple
45
0.880.85-0.91]
0.910.88-0.93]
10.07.5-13.3]
0.130.10-0.17]
7950-126]
0.960.93-0.97]
Smoking status
only smokers
4
0.800.70-0.87]
0.860.77-0.91]
5.63.2-9.9]
0.230.14-0.38]
249-66]
0.900.87-0.92]
S+NS (imbalanced)
6
0.880.74-0.95]
0.900.73-0.97]
9.23.0-28.2]
0.130.05-0.31]
7114-360]
0.950.93-0.97]
S+NS (balanced)
18
0.830.74-0.90]
0.860.80-0.90]
5.93.9-8.8]
0.190.12-0.32]
3013-69]
0.910.88-0.93]
unknown status
43
0.860.82-0.89]
0.880.85-0.91]
7.35.7-9.4]
0.160.12-0.21]
4630-70]
0.930.91-0.95]
Specimen
plasma
22
0.820.76-0.87]
0.87[0.83-0.90]
6.34.6-8.5]
0.200.15-0.28]
3118-52]
0.920.89-0.94]
serum
19
0.910.86-0.95]
0.850.79-0.89]
6.14.3-8.5]
0.100.06-0.17]
6028-128]
0.940.91-0.95]
Whole blood/blood cell
9
0.840.78-0.89]
0.920.80-0.97]
10.93.9-30.3]
0.170.11-0.26]
6417-234]
0.920.89-0.94]
not blood
21
0.800.72-0.86]
0.890.85-0.93]
7.54.9-11.7]
0.220.16-0.32]
3416-71]
0.920.89-0.94]
Ethnicity
Asian
41
0.820.77-0.85]
0.860.82-0.88]
5.74.5-7.2]
0.210.17-0.27]
2718-40]
0.910.88-0.93]
Caucasian
18
0.910.86-0.95]
0.920.87-0.96]
127.0-20.4]
0.090.06-0.15]
12754-302]
0.970.95-0.98]
Caucasian/African
12
0.850.72-0.93]
0.870.81-0.91]
6.64.6-9.4]
0.170.09-0.33]
3917-88]
0.920.89-0.94]
Control-type
BPD
13
0.840.77-0.89]
0.840.80-0.88]
5.34.1-6.8]
0.190.13-0.28]
2716-46]
0.90[0.87-0.92]
HC
50
0.86[0.82-0.89]
0.88[0.85-0.91]
7.4[5.7-9.5]
0.16[0.12-0.21]
4730-74]
0.94[0.91-0.95]
BPD, HC
8
0.81[0.67-0.90]
0.91[0.79-0.96]
8.8[3.4-22.9]
0.21[0.11-0.40]
429-187]
0.93[0.90-0.95]
Stage
I-II
18
0.84[0.78-0.89]
0.90[0.86-0.93]
8.3[5.8-11.9]
0.17[0.12-0.25]
4827-87]
0.94[0.91-0.96]
I-IV
50
0.86[0.82-0.89]
0.88[0.84-0.90]
6.5[5.4-8.7]
0.16[0.13-0.22]
4227-66]
0.93[0.90-0.95]
No. of cases
small
25
0.88[0.82-0.92]
0.91[0.88-0.94]
10.0[7.1-14.2]
0.14[0.09-0.21]
7438-143]
0.95[0.93-0.97]
large
46
0.84[0.79-0.87]
0.86[0.82-0.88]
5.8[4.6-7.2]
0.19[0.15-0.24]
3120-46]
0.91[0.89-0.94]
MiR-210
12
0.77[0.72-0.81]
0.93[0.88-0.96]
11.0[6.2-19.4]
0.25[0.20-0.31]
4422-87]
0.91[0.88-0.93]
MiR-21
16
0.82[0.77-0.86]
0.87[0.84-0.89]
6.3[5.0-8.1]
0.21[0.15-0.28]
3119-50]
0.91[0.88-0.93]
No: the number of the studies; HC: healthy control; BPD: benign pulmonary disease; SEN: sensitivity; SPE: specificity; PLR: positive likelihood ratio; NLR:negative likelihood ratio; DOR: diagnostic odds ratio; AUC:area under the curve; no. of case: small (<50) and large (≥50). S: smokers; NS: nonsmokers; imbalanced: the smoking status was imbalanced between groups; balanced: the smoking status was balanced between groups.
