| | Characteristic | Overall | CrCl 80 ml/min
| CrCl 50–79 ml/min
| value |
| | Age, y | | | | | | Mean (SD) | 56.2 (13.5) | 57.7 (13.4) | 53.0 (13.2) | 0.89 | | Minimum, maximum | 19, 91 | 19, 91 | 22, 75 | | | Female sex, % | 59.6 | 46.7 | 86.4 | 0.01 | | BMI | | | | 0.03 | | Mean (SD) | 22.8 (4.4) | 23.1 (4.7) | 22.0 (3.7) | | | Minimum, maximum | 14, 39 | 14.0, 39.0 | 16.0, 34.0 | | | LVEF | | | | | | Mean (SD) | 60.4 (10.1) | 59.7 (10.9) | 62.0 (8.0) | 0.76 | | Minimum, maximum | 29.0, 75.0 | 29.0, 75.0 | 45.0, 75.0 | | | ESR | | | | 0.77 | | Mean (SD) | 17.8 (12.5) | 16.1 (11.7) | 18.6 (16.4) | | | Minimum, maximum | 3, 77 | 2.0, 60.0 | 3.0, 77.0 | | | Antistreptolysin “O” | | | | 0.95 | | Mean (SD) | 83.6 (70.2) | 78.7 (73.0) | 94.8 (63.5) | | | Minimum, maximum | 11, 365 | 11, 365 | 17, 261 | | | BNP | | | | | | Mean (SD) | 1808.8 (2213.6) | 1873.1 (2300.6) | 1674.2 (2038.3) | 0.63 | | Minimum, maximum | 7.2, 9236.0 | 7.2, 9036.0 | 21.7, 6778.0 | | | Hb | | | | | | Mean (SD) | 132.5 (22.1) | 136.8 (21.7) | 123.5 (20.4) | 0.01 | | Minimum, maximum | 65.0, 259.0 | 69.0, 259.0 | 65.0, 155.0 | | | PLT | | | | | | Mean (SD) | 201.8 (62.2) | 203.4 (60.8) | 198.4 (65.7) | 0.66 | | Minimum, maximum | 70.0, 495.0 | 70.0, 495.0 | 116.0, 444.0 | | | CRP | | | | | | Mean (SD) | 10.7 (13.4) | 10.7 (13.2) | 10.7 (14.1) | 0.99 | | Minimum, maximum | 2, 76 | 2.0, 71.0 | 2, 76 | | | ALT | | | | | | Mean (SD) | 26.5 (21.8) | 26.6 (19.1) | 26.3 (26.7) | 0.94 | | Minimum, maximum | 8.0, 173.0 | 8.0, 173.0 | 9.0, 66.0 | | | AST | | | | | | Mean (SD) | 28.1 (23.6) | 28.9 (26.5) | 26.1 (15.8) | 0.52 | | Minimum, maximum | 6.0, 189.0 | 6.0, 189.0 | 8.0, 69.0 | | | NYHA class III/IV, % | 38.40% | 37.50% | 39.20% | 0.67 | | Hypertension, % | 27.2 | 26.1 | 29.5 | 0.69 | | Diabetes mellitus, % | 8.8 | 8.7 | 9.1 | 0.47 | | Medications | | | | | | ASA, % | 47.8 | 44.8 | 48.8 | 0.32 | | ARB, % | 33.1 | 33.3 | 32.1 | 0.54 | | ACEI, % | 28.1 | 29.2 | 27.5 | 0.44 | | ß-blocker, % | 46.7 | 47.7 | 44.3 | 0.17 | | Warfarin, % | 4.7 | 4.5 | 4.9 | 0.74 | | Clopidogrel, % | 13.9 | 14.6 | 13.2 | 0.58 |
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BMI indicates body mass index; ESR, erythrocyte sedimentation rate; LVEF, left ventricular ejection; BNP, brain natriuretic peptide; PLT, platelet; CRP, C reactive protein; ALT, alanine aminotransferase; AST, glutamate oxaloacetate transaminase; Hb, hemoglobin; NYHA class, New York Heart Association functional class; ARB, angiotensin receptor blocker; ACEI, angiotensin-converting enzyme inhibitor.
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