Research Article
The Immunogenicity of the C Fragment of Tetanus Neurotoxin in Production of Tetanus Antitoxin
Table 1
Horse groups and immunization schedule and doses.
| | Schedule | Number of shots | Group 1 (mg) | Group 2 (mg) | Group 3 (mg) | Group 4 (mg) | Group 5 (mg) | Group 6 (mg) | Routine TT immunization (mg) |
| | Stage 1 Phase 1 (Basic) | 1 | TeNT-Hc 0.625 | TeNT-Hc 1.25 | TeNT-Hc 0.625 | TeNT-Hc 0.625 | TT 0.625 | Mix Ag 0.625 | TT 0.625 | | 2 | TeNT-Hc 1.875 | TeNT-Hc 3.75 | TeNT-Hc 1.875 | TeNT-Hc 1.875 | TT 1.875 | Mix Ag 1.875 | TT 1.875 |
| Stage 1 Phase 2
(Hyperimmunization) | 1 | TeNT-Hc 1.25 | TeNT-Hc 1.875 | TT 1.25 | TeNT-Hc 1.25 | TeNT-Hc 1.25 | Mix Ag 1.25 | TT 1.25 | | 2 | TeNT-Hc 2.5 | TeNT-Hc 3.75 | TT 2.5 | TeNT-Hc 2.5 | TeNT-Hc 2.5 | Mix Ag 2.5 | TT 2.5 | | 3 | TeNT-Hc 3.75 | TeNT-Hc 5.625 | TT 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | Mix Ag 3.75 | TT 3.75 | | 4 | TeNT-Hc 5 | TeNT-Hc 7.5 | TeNT-Hc 5 | TT 5 | TeNT-Hc 5 | Mix Ag 5 | TT 5 | | 5 | TeNT-Hc 5 | TeNT-Hc 7.5 | TeNT-Hc 5 | TT 5 | TeNT-Hc 5 | Mix Ag 5 | TT 5 | | 6 | TeNT-Hc 7.5 | TeNT-Hc 11.25 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | Mix Ag 7.5 | TT 7.5 | | 7 | TeNT-Hc 10 | TeNT-Hc 15 | TeNT-Hc 10 | TeNT-Hc 10 | TeNT-Hc 10 | Mix Ag 10 | TT 10 |
| | Stage 2 | 1 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | Mix Ag 3.75 | TT 3.75 | | 2 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | Mix Ag 7.5 | TT 7.5 | | 3 | TeNT-Hc 15 | TeNT-Hc 15 | TeNT-Hc 15 | TeNT-Hc 15 | TeNT-Hc 15 | Mix Ag 15 | TT 15 |
| | Stage 3 | 1 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | TeNT-Hc 3.75 | Mix Ag 3.75 | TT 3.75 | | 2 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | TeNT-Hc 7.5 | Mix Ag 7.5 | TT 7.5 | | 3 | TeNT-Hc 15 | TeNT-Hc 15 | TeNT-Hc 15 | TeNT-Hc 10 | TeNT-Hc 15 | Mix Ag 15 | TT 15 |
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