Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma

Figure 5

TRIM24 increases glucose metabolism in HNSCC. (a) TRIM24 depletion in FaDu cells reduced glucose consumption while TRIM24 overexpression increased glucose consumption in Detroit 562 cells. (b) TRIM24 depletion reduced ATP production in FaDu cells while TRIM24 overexpression upregulated ATP production in Detroit 562 cells. (c) Cell growth was examined after 3 days of glucose deprivation. With glucose deprivation, the cell viability of control cells was higher than that of TRIM24 overexpressed Detroit 562 cells and lower than TRIM24 depleted FaDu cells. (d) ChIP assay was performed in FaDu and Detroit 562 cells. Data were presented as fold enrichment of the TRIM24 antibody signal versus the control IgG, calculated using the comparative Ct method. significance.

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