Research Article

Risk Factors for Neonatal Sepsis: A Retrospective Case-Control Study among Neonates Who Were Delivered by Caesarean Section at the Trauma and Specialist Hospital, Winneba, Ghana

Table 3

Neonatal risk factors that influence early neonatal sepsis.

VariableCases
n=55()
Controls
n=128()
Total
N=183()
Chi-square, 2
(p-value)
COR [95CI]
p-value
AOR [95CI]
p-value

Gestational age (weeks)
<3713 (23.6)18 (14.1)31 (16.9)2.17 [0.38, 12.49] 0.387
37-4240 (72.7)104 (81.2)144 (78.7)1.15 [0.22, 5.96] 0.864
>422 (3.6)6 (4.7)8 (4.4)2.54 (0.282)Ref.
Birth weight (Kg)
<1.58 (14.5)5 (3.9)13 (7.1)3.96 [1.22, 12.87] 0.0221.91 [0.46, 7.92] 0.372
1.5-2.59 (16.4)29 (22.7)38 (20.8)0.77 [0.33, 1.77] 0.5360.56 [0.19, 1.66] 0.298
>2.538 (69.1)94 (73.4)132 (72.1)6.96 (0.031)Ref.Ref.
Sex
Male28 (50.9)59 (46.1)87 (47.5)Ref.
Female27 (49.1)69 (53.9)96 (52.5)0.36 (0.550)0.82 [0.44, 1.55] 0.550
APGAR score in the first minute
<723 (41.8)27 (21.1)50 (27.3)2.69 [1.36, 5.33] 0.0051.40 [0.46, 4.27] 0.550
≥732 (58.2)101 (78.9)133 (72.7)8.32 (0.004)Ref.Ref.
APGAR score in the fifth minute
<715 (27.3)17 (13.3)32 (17.5)2.45 [1.12, 5.36] 0.0251.70 [0.46, 6.36] 0.426
≥740 (72.7)111 (86.7)151 (82.5)5.22 (0.022)Ref.Ref.
Meconium
None8 (14.6)55 (43.0)63 (34.4)Ref.Ref.
Passed47 (85.4)73 (57.0)120 (65.6)13.77 (<0.001)4.43 [1.94, 10.12] <0.0010.82 [0.21, 3.18] 0.775
Resuscitated at birth
No45 (81.8)108 (84.4)153 (83.6)Ref.
Yes10 (18.2)20 (15.6)30 (16.4)0.18 (0.668)1.20 [0.52, 2.77] 0.669
Reason for CS
Emergency48 (87.3)69 (53.9)117 (63.9)Ref.Ref.
Elective7 (12.7)59 (46.1)66 (36.1)18.57 (<0.001)0.17 [0.07, 0.41] <0.0010.25 [0.09, 0.68] 0.006
Duration of stay
< 1 week37 (67.3)122 (95.3)159 (86.9)Ref.Ref.
1-2 weeks8 (14.5)5 (3.9)13 (7.1)5.28 [1.62, 17.10] 0.0063.50 [0.96, 12.73] 0.057
<2 weeks10 (18.21 (0.8)11 (6.0)28.99 (<0.001)32.97 [4.09, 266.13] <0.00134.44 [3.06, 388.02] 0.004
Outcome of admission
Discharged49 (89.1)120 (93.7)169 (92.4)Ref.
Died4 (7.3)7 (5.5)11 (6.0)1.40 [0.39, 4.99] 0.605
Referred2 (6.6)1 (0.8)3 (1.6)2.21 (0.331)4.90 [0.43,55.27] 0.199