Epstein Barr Virus Infection Affects Function of Cytotoxic T Lymphocytes in Patients with Severe Aplastic Anemia

Table 3

Function, apoptosis, and proliferation of CD8+ T cells transfected with EBNA-1-siRNA or siRNA negative control plasmid.

		EBNA-1-siRNA	siRNA negative control	value
Granzyme B (%)	10	48.32 ± 7.10	56.42 ± 8.79	0.02
Perforin (%)	10	5.26 ± 1.11	6.42 ± 1.39	0.03
Apoptosis rate (%)	10	13.78 ± 5.99	12.75 ± 4.96	0.48
Proliferation activity	10	0.41 ± 0.10	0.47 ± 0.07	0.03
IFN-γ (ng/L)	10	17.13 ± 4.35	20.73 ± 5.21	0.04
IL-4 (ng/L)	10	14.47 ± 3.48	14.64 ± 2.66	0.85