Research Article

Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent

Figure 2

Western blot detection of claudin-5 (means ± SD, n = 3). test1: the group with continuous launches and ultrasonic contrast agent (1 ml/kg). test2: the group with intermittent launches (interval time of 400 ms) and ultrasonic contrast agent (1 ml/kg). Claudin-5 was reduced in the CEUS groups (test1 and test2) compared with the control group, and the reduction is especially pronounced in the intermittent group (test2).