Pharmacokinetic Interaction Study of Ketamine and Rhynchophylline in Rat Plasma by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry

Table 4

Primary pharmacokinetic parameters after intraperitoneal administration of rhynchophylline in rats (n = 6).

Parameters	Unit	Rhynchophylline	Ketamine + rhynchophylline
	ng/mLh	1090.9 ± 710.8	2620.0 ± 1291.2
	ng/mLh	1094.8 ± 715.1	2650.3 ± 1269.4
	h	2.9 ± 0.7	1.8 ± 0.5
	h	2.9 ± 0.8	3.1 ± 2.6
t1/2	h	2.9 ± 2.2	11.5 ± 19.1
CL	L/h/kg	40.9 ± 29.0	13.3 ± 5.1
V	L/kg	146.3 ± 100.5	264.0 ± 473.0
	ng/mL	314.9 ± 162.1	1133.7 ± 433.9

Compared to ketamine group, , .