Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion

Table 3

Genes up-regulated in WM with 6q del compared with WM without 6q del.

Function categories	Up-regulated gene
B-cell receptor signaling pathway	CD79a, SYK, BLNK, PLCγ2, CARD11
IL21/21R signaling pathway	IL21R, JAK3
NF-kB activater	FOXP1
Ubiqutin ligase	CBLB
Ikaros zinc finger family	IFZF3
Cytokines	IFNγ
Other genes	MSH6, IMPDH2, AKAP17A, CCR7, MEF2C, POU2F2, ITPKB, BANK1, IL7R, LAX1, ERCC1, PRKCB, KLRC4-KLRK, HDAC9, ITGAL, GON4L, PSEN1, RHOH, PSEN1

WM, Waldenstrom macroglobulinemia.