Research Article

Self-Nanoemulsifying Drug Delivery System of Tetrandrine for Improved Bioavailability: Physicochemical Characterization and Pharmacokinetic Study

Table 3

Pharmacokinetic parameters of Tet SNEDDS formulation and Tet commercial tablet after single dose administration (n=6).

ParametersUnitSNEDDSTablet

ng/mL h33855.6±2024.14459.4±3131.4
ng/mL h41078.4±3621.17604.0±4337.3
h3.8±1.6.6±1.6
ng/mL1234.8±39.519.3±26.8
MRTh39.6±10.239.9±12.1
Relative bioavailability233.3%

<0.05 compared to the Tet commercial tablet.