Review Article

Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression

Table 2

Aberrant miRNAs associated with the cell cycle and apoptosis.

MicroRNAsType of deregulationTargetReference

miR-199a/b-3pDownregulatedCyclin D1[15]
miR-302bDownregulatedEGFR, Cyclin A, Cyclin D1, CDK2[16, 17]
miR-184UpregulatedSOX7[18]
miR-200aDownregulatedCDK6[19]
miR-19aDownregulatedCyclin D1[20]
miR125a-5p, miR-125bDownregulatedsirtuin7, SUV39H1[21, 22]
miR-140DownregulatedTGFBR1, FGF9[23]
miR-497, miR-195UpregulatedCCNE1, CDC25A, CCND3, CDK4,[24]
miR-451Downregulatedcyclin D1, c-Myc[25]
miR-517a, miR-17cUpregulatedPyk2[26]
miR-371-5pDownregulatedPRPF4B[27]
miR-221, miR-1228Upregulatedp53[28, 29]
miR-1269UpregulatedFOXO1[30]
miR-148aUpregulatedPTEN[31]
miR-1228Upregulatedp53[32]
miR-138UpregulatedCyclin D3[33]
miR-141DownregulatedHNF-3beta[34]
miR-24UpregulatedSOX7[35]
miR-133aUpregulatedAKT, ERK[36]
miR-129-5pDownregulatedVCP[37]
miR-122UpregulatedGalpha12[38, 39]
miR-93UpregulatedPTEN, CDKN1A[40]
miR-105UpregulatedAKT1[41]
miR-125bUpregulatedBcl-w, IL6R[42]
miR-34aUpregulatedUFC1[43]
miR-383DownregulatedAPRIL[44]
miR-221DownregulatedBmf[45]