Small but Heavy Role: MicroRNAs in Hepatocellular Carcinoma Progression

Table 4

Role of miRNAs in the tumor microenvironment.

MicroRNAs	Type of deregulation	Target	Reference
miR-214	Upregulated	HDGF	[61]
miR-125b	Upregulated	placenta growth factor	[62]
miR-29b	Downregulated	MMP-2	[63]
miR-21	Downregulated	hSulf-1, PTEN	[64]
miR-26a	Downregulated	VEGFA	[65]
miR-195	Downregulated	VEGF, VAV2, CDC42	[66]
miR-503	Downregulated	FGF2, VAGFA	[67]
miR-146a	Upregulated	PDGFRA	[68]
miR-126-3p	Upregulated	LRP6, PIK3R2	[69]
miR-26a	Downregulated	c-MET	[70]
miR-302c	Downregulated	VEGFA, AEG-1	[71]
miR-497	Downregulated	PRC2	[72]
miR101	Downregulated	EZH2, EED	[73]
miR-148a-5p/miR-363-3p	Downregulated	MYC	[74]
miR-139	Downregulated	ROCK2	[75]
miR-188-5p	Downregulated	FGF5	[76]
miR-375	Downregulated	AEG-1	[77]
miR-122	Upregulated	pyruvate kinase M2	[78]
miR-146a	Upregulated	TGF-β, IL-17, VEGF, I IFN	[79]
miR-224	Upregulated	Smad4	[80, 81]
miR-34a	Downregulated	CCL22	[82]
miR-148a	Downregulated	ACVR1	[83]