Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Table 2

Comparison of propofol and fospropofol characteristics according to [14, 26–29].

Characteristics	Propofol	Fospropofol
Standard dose to induce general anesthesia	1.5–2.5 mg/kg (lipid emulsion formulation)	6.5 mg/kg (aqueous formulation)
Onset of action	40 s–1 min (“one arm-brain circulation”)	4–8 min
Duration of action after bolus dose	3–10 min	5–18 min
Volume of distribution (L/kg)	5.8	0.3
Total body clearance (L/h/kg)	3.2	0.36
Terminal phase elimination half-life (h)	0.97	0.88
Protein binding (%), mostly albumin	97–99	95–97
Side effect	Pain on injection and moderate to severe cardiovascular and respiratory depression	Transient perineal paresthesia, pruritus and mild cardiovascular and respiratory depression