(a) Subgroup analysis of the association between statin therapy and incidence of liver injury defined by dosage of statin. The area of each square is proportional to the inverse of the variance of the log relative risks. Horizontal lines represent the 95% CIs. Diamonds represent pooled estimates from an inverse variance-weighted random effects model |

(b) Subgroup analysis of the association between statin therapy and incidence of liver injury defined by type of statin. The area of each square is proportional to the inverse of the variance of the log relative risks. Horizontal lines represent the 95% CIs. Diamonds represent pooled estimates from an inverse variance-weighted random effects model |

(c) Subgroup analysis of the association between statin therapy and incidence of liver injury defined by duration of statin therapy. The area of each square is proportional to the inverse of the variance of the log relative risks. Horizontal lines represent the 95% CIs. Diamonds represent pooled estimates from an inverse variance-weighted random effects model |

Review Article