CT Myocardial Perfusion Imaging: A New Frontier in Cardiac Imaging

Table 4

Dynamic CTP imaging in human study.

Author; (Year)	Patients; No.	CT; Scanner	CTP Protocol	Stress Agent; (dose)	Analysis	Reference; Standard	SE (%)	SP (%)	PPV (%)	NPV (%)	Average CT; Dose
Bastarrika et al [72]; (2010)	10	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Visual; Semiq; Quantitative MBF	MRI; (segment)	86	98	94	96	12.5; mSv
Ho et al [73]; (2010)	35	DS (2nd)		Dypiridamole; (0.56 mg/Kg in 4′)	Quantitative MBF	SPECT; (segment)	83	78	79	82	9.1; mSv
Bamberg et al [74]; (2011)	33	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Quantitative MBF	FFR^§; (vessel)	93	87	75	97	10; mSv
Wang et al [75]; (2012)	30	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Visual; Quantitative MBF and MBV	QCA + SPECT; (vessel)	100	76	54	100	9.5; mSv
Greif et al [55]; (2013)	65	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Quantitative MBF	FFR; (vessel)	95	74	49	98	9.7; mSv
Huber et al [76]; (2013)	32	256-slice		Adenosine; (0.14 mg/kg/min)	Quantitative MBF	FFR; (vessel)	76	100	100	91	9.5; mSv
Bamberg et al [77]; (2014)	31	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Quantitative MBF and MBV	MRI 3T; (vessel)	100	75	92	100	11.08; mSv
Rossi et al [78]; (2014)	80	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Quantitative MBF	FFR; (vessel)	88	90	77	95	9.4; mSv

CTP, computed tomography perfusion; 2nd, second generation; CT, computed tomography; CCTA, coronary computed tomography angiography; PROSP, Prospective ECG-gating acquisition; DS, Dual-Source scanner; FFR, fractional flow reserve; MRI, magnetic resonance imaging; MBF, myocardial blood flow; MBV, myocardial blood volume; No., patients’ number; NPV, negative predictive value; PPV, positive predictive value; QCA, quantitative coronary angiography; SE, sensitivity; Semiq, semiquantitative analysis; SP, specificity; SPECT, myocardial perfusion scan; ^§, accuracy of CT perfusion integrated with the coronary anatomic data.