CT Myocardial Perfusion Imaging: A New Frontier in Cardiac Imaging

Table 5

Dynamic CTP imaging in animal studies.

Author; (Year)	No.	CT; Scanner	CTP; Protocol	Stress; Agent; (dose)	Reference; Standard	Analysis	Dose
Bamberg et al [82]; (2012)	7 pigs	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Microsphere MBF	Quantitative MBF	10.6; (mSv)
Rossi et al [83]; (2013)	7 pigs	DS (2nd)		Adenosine; (0.50 mg/kg/min)	CBF and FFR	Quantitative MBF	17.1; (mSv)
Schwarz et al [84]; (2013)	6 pigs	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Microsphere MBF	Quantitative MBF + attenuation values (HU)	11.3; + 0.88; (mSv)
Bamberg et al [85]; (2014)	12 pigs	DS (2nd)		Adenosine; (0.14 mg/kg/min)	Histopathology; Microsphere MBF	Quantitative MBF, MBV,	NA

2nd, second generation; No., number of animals; CT, computed tomography; CBF, coronary blood flow; CTP, CT perfusion imaging; DS, Dual-Source scanner; FFR, fractional flow reserve; HU: Hounsfield Unit; Ktrans, permeability constant; MBF, myocardial blood flow; MBV, myocardial blood volume; NA, nonassessable.