Drosophila as a Model System to Study Cell Signaling in Organ Regeneration

Figure 1

Drosophila wing imaginal discs regeneration process. After a cut or genetic ablation in the third instar wing imaginal discs various cellular processes occur. First, four hours after cut (AC), the wound heals restoring the epithelial continuity. Around 24 hours AC, some cells lose expression of markers of cell fate commitment. Finally, the pattern is restored and the discs give rise to a normal pattern and sized adult wings. However, there is a delay in pupariation to allow the tissue to regenerate.