Research Article
Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population
Table 3
Genotype distribution and allele frequency of AKT1 mutations in cases and controls.
| | Mutations | Genotypes | Genotypic frequency | Allele frequency | | Cases | Controls | All | Cases | Controls | All |
| rs121434592
E17K | GG | 0.98 | 1.00 | 0.99 | 0.98 | 1.00 | 0.99 | | GA | 0.00 | 0.00 | 0.00 | | | | | AA | 0.02 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 |
| rs12881616
E319G | AA | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | | AG | 0.00 | 0.00 | 0.00 | | | | | GG | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| rs11555432
L357P | TT | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | | TC | 0.00 | 0.00 | 0.00 | | | | | CC | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| rs11555431
P388T | CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | | CA | 0.00 | 0.00 | 0.00 | | | | | AA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| | rs2494732 | CC | 0.45 | 0.30 | 0.34 | 0.65 | 0.54 | 0.57 | | CT | 0.41 | 0.48 | 0.46 | | | | | TT | 0.14 | 0.22 | 0.20 | 0.35 | 0.46 | 0.43 |
| | rs3803304 | CC | 0.59 | 0.65 | 0.63 | 0.76 | 0.82 | 0.80 | | CG | 0.33 | 0.33 | 0.33 | | | | | GG | 0.08 | 0.02 | 0.04 | 0.24 | 0.18 | 0.20 |
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