Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population

Table 4

Association between rs2494732 and rs3803304 polymorphisms and breast cancer risk among cases and controls.

Mutations	Genotypes	Cases ( = 91),; (%)	Controls ( = 185),; (%)	OR	95% CI	P value	FDR; Q value
rs2494732	CC	41 (45)	56 (30)	1.0	Reference
	CT	37 (41)	89 (48)	0.6	0.3 – 1.0	P > 0.05	Q > 0.05
	TT	13 (14)	40 (22)	0.4	0.2 – 0.9	P ≤ 0.05	Q > 0.05
	CT+TT	50 (55)	129 (70)	0.5	0.3 – 0.9	P ≤ 0.05	Q > 0.05
rs3803304	CC	54 (59)	121 (65)	1.0	Reference
	CG	30 (33)	61 (33)	1.1	0.6 – 1.9	P > 0.05	Q > 0.05
	GG	7 (8)	3 (2)	5.2	1.3 – 20.9	P ≤ 0.05	Q > 0.05
	CG+GG	37 (41)	64 (35)	1.3	0.8 – 2.2	P > 0.05	Q > 0.05

OR, odds ratio; CI, confidence interval; FDR, false discovery rate.
References.