Research Article
Mutational Analysis of Oncogenic AKT1 Gene Associated with Breast Cancer Risk in the High Altitude Ecuadorian Mestizo Population
Table 4
Association between rs2494732 and rs3803304 polymorphisms and breast cancer risk among cases and controls.
| Mutations | Genotypes | Cases ( = 91), (%) | Controls ( = 185), (%) | OR | 95% CI | P value | FDR Q value |
| rs2494732 | CC | 41 (45) | 56 (30) | 1.0 | Reference | CT | 37 (41) | 89 (48) | 0.6 | 0.3 – 1.0 | P > 0.05 | Q > 0.05 | TT | 13 (14) | 40 (22) | 0.4 | 0.2 – 0.9 | P ≤ 0.05 | Q > 0.05 | CT+TT | 50 (55) | 129 (70) | 0.5 | 0.3 – 0.9 | P ≤ 0.05 | Q > 0.05 |
| rs3803304 | CC | 54 (59) | 121 (65) | 1.0 | Reference | CG | 30 (33) | 61 (33) | 1.1 | 0.6 – 1.9 | P > 0.05 | Q > 0.05 | GG | 7 (8) | 3 (2) | 5.2 | 1.3 – 20.9 | P ≤ 0.05 | Q > 0.05 | CG+GG | 37 (41) | 64 (35) | 1.3 | 0.8 – 2.2 | P > 0.05 | Q > 0.05 |
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OR, odds ratio; CI, confidence interval; FDR, false discovery rate. References. |