Review Article

Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery: An Update Meta-Analysis and Trial Sequential Analysis

Table 2

Secondary endpoints after randomizations.

Secondary outcomesNumber of studies95% CI (heterogeneity) (%) (overall effect)

Cardiac index (L/min/m2)70.66 [0.62, 0.70]<0.0000189<0.00001
Pulmonary capillary wedge pressure (mmHg)7−2.35 [−2.78, −1.93]0.00173<0.00001
Postoperative atrial fibrillation110.97 [0.85, 1.09]0.0006680.60
Postoperative renal replacement therapy80.51 [0.33, 0.77]0.8600.002
Length of ICU stay (days)10−0.48 [−0.72, −0.24]<0.0000185<0.0001