2<sup>3</sup> Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach

<table class="fixed-width table-group" id="tab4"><tr><td><table class="table"><colgroup><col style="width:4.91em"/><col style="width:9.29em"/><col style="width:6.46em"/></colgroup><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left"><b>Variable</b></td><td class="align_center"><b>Coded value</b></td><td class="align_center"><b>Actual value</b></td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Chitosan</td><td class="align_center">-0.595</td><td class="align_center">1.2mg/ml</td></tr><tr><td class="align_left">TPP</td><td class="align_center">-0.005</td><td class="align_center">0.9mg/ml</td></tr><tr><td class="align_left">MTX</td><td class="align_center">0</td><td class="align_center">45mg</td></tr><tr><td class="align_left" colspan="3"><hr/></td></tr><tr><td class="align_left"> </td><td class="align_center"><b><i>Predicted value</i></b></td><td class="align_center">180nm</td></tr><tr><td class="align_left"> </td><td class="align_center"><b><i>Experimental value</i></b></td><td class="align_center">176±4nm</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Validation of optimized formulation by experimental design.</div>

BioMed Research International

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Table 4

Table 4: 2<sup>3</sup> Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach 

BioMed Research International

23 Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach

Table 4

2³ Full Factorial Model for Particle Size Optimization of Methotrexate Loaded Chitosan Nanocarriers: A Design of Experiments (DoE) Approach