Technetium-99 Conjugated with Methylene Diphosphonate Ameliorates Glucocorticoid Induced Osteoporosis by Inhibiting Osteoclastogenesis
Table 1
Microstructural quantitative analysis of cancellous and cortical bone in six groups
Parameters
Blank
Negative control
High Dose
Medium Dose
Low Does
Positive Control
BV/TV
0.386 ± 0.048
0.326 ± 0.032
0.471 ± 0.086
0.421 ± 0.042
0.416 ± 0.065
0.449 ± 0.064
BS/BV (mm−1)
36.64 ± 3.08
39.84 ± 2.29
34.56 ± 4.71
36.37 ± 3.78
39.93 ± 3.81
34.49 ± 3.78
Tb.Th (mm)
0.0549 ± 0.0048
0.0503 ± 0.0029
0.0588 ± 0.0079
0.0555 ± 0.0057
0.0546 ± 0.0053
0.0587 ± 0.0071
Tb.N (mm−1)
7.008 ± 0.468
6.466 ± 0.480
7.980 ± 0.669
7.607 ± 0.469
7.591 ± 0.784
7.640 ± 0.452
Tb.Sp (mm)
0.0883 ± 0.0123
0.1051 ± 0.0131
0.0673 ± 0.0156
0.0764 ± 0.0085
0.0783 ± 0.0160
0.0702 ± 0.0117
TBPf (mm−1)
-1.08 ± 2.36
2.87 ± 1.36
-8.10 ± 6.65
-4.33 ± 3.54
-3.37 ± 4.52
-5.62 ± 4.50
Ct.Th (mm)
0.344 ± 0.0237
0.293 ± 0.0206
0.345 ± 0.0382
0.343 ± 0.0365
0.329 ± 0.0155
0.303 ± 0.0191
Data are presented as mean ± standard deviation. BV/TV: bone volume/total volume; BS/BV: bone surface area/bone volume; Tb.Th: trabecular thickness; Tb.N: trabecular number; Tb.Sp: trabecular spacing; TBPf: trabecular bone pattern factor; and Ct.Th: cortical thickness. All other five groups are compared with negative control group (group B), respectively. p < 0.05. p < 0.01. p < 0.001.
