Research Article

Melatonin Modulation of Sirtuin-1 Attenuates Liver Injury in a Hypercholesterolemic Mouse Model

Table 1

Liver/body weight ratio and serum parameters.

ApoE−/−  
6 weeks
ApoE−/−  
15 weeks
Control
6 weeks
Control
15 weeks
ApoE−/− plus melatonin
15 weeks

Liver/body weights (%)5.45.555.25.1
Cholesterol (mg/dL)
Triglycerides (mg/dL)

versus ApoE−/− (6 weeks old); versus ApoE−/− (15 weeks old); versus control mice (6 weeks old);   versus control mice (15 weeks old).