Review Article

A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications

Table 2

Mechanism and biological function of downregulated LncRNAs in HCC.

lncRNAFull nameMechanismFunctionReference

H19NoneActivating miR-200 family, downregulating AKT/GSK-3beta/Cdc25A pathwayMigration(−), invasion(−), metastasis(−), EMT(−)[64, 68]

MEG3Maternally expressed gene 3Activating P53, MEG3/miR664/ADH4 axisProliferation(−), apoptosis(+),[72, 73, 76]

DrehDownregulated by HBxDownregulating vimentinProliferation(−), migration(−), metastasis(−)[77]

LETLow expression in tumorDownregulating NF90Invasion(−), metastasis(−)[79]

ZNFX1-AS1ZNFX1 antisense RNA 1Upregulating miR-9Proliferation(−), apoptosis(+),[135]

PTENP1Phosphatase and tensin homolog, pseudogene 1Downregulating miR-17,
miR-19b, and miR-20a
Proliferation(−), angiogenesis(−), apoptosis(+), autophagy(+)[136]

AOC4PAmine oxidase, copper containing 4, pseudogeneDownregulating vimentinProliferation(−), migration(−),
invasion(−), EMT(−)
[137]

FTXNoneDownregulating miR-374a and Wnt/β-catenin signalingProliferation(−), invasion(−),
metastasis(−), EMT(−),
[138]

XISTX inactive specific transcriptXIST/miR-181a/PTEN axis; XIST/miR-92b/Smad7 axisProliferation(−), invasion(−),
metastasis(−)
[139, 140]

LncRNA00364NoneLncRNA00364/STAT3/IFIT2 axisProliferation(−), apoptosis(+),
G1/S cell cycle progression(−),
[141].

Linc-USP16NoneceRNA for miR-21 and miR-590-5p and upregulating PTENProliferation(−), migration(−)[142]

CASC2Cancer susceptibility candidate 2Downregulating miR-24-3p, CASC2/miR-367/FBXW7 axisProliferation(−), apoptosis(+),
migration(−), invasion(−), EMT(−)
[143, 144]

LINC00657NoneLINC00657/miR-106a-5p /PTEN axisProliferation(−), migration(−), invasion(−)[145].

FER1L4Fer-1-like protein 4Downregulating miR-106-5pProliferation(−), migration(−),
invasion(−), apoptosis(+)
[146]

uc.134Noneuc.134/CUL4A/LATS1 axisProliferation(−), invasion(−), metastasis(−)[75]

lnc-DILClncRNA downregulated in liver cancer stem cellsIL-6/STAT3 axisProliferation(−)[147]

+: increase; −: decrease.