p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis

Table 1

Overview of p300/CBP regulates liver lipid, glucose metabolism, and liver fibrosis through regulating different targets.

Progress	Activity	Targets	Effect	Nutritional state	Metabolic response	Reference
Lipid metabolism	Acetylation	FXR	Inhibitory	High glucose and insulin	Lipogenesis↑; Gluconeogenesis↑	[17, 18]
	Acetylation	ChREBP	Stimulatory	High glucose and insulin	Lipogenesis↑	[19]
	Acetylation	SREBP1c	Stimulatory	High glucose and insulin	Lipogenesis↑	[20]
	Binding	DDX3	Stimulatory	/	Lipid export↑	[21]
Glucose metabolism	Acetylation	FOXO1	Stimulatory	Fasting state	Gluconeogenesis↑	[22]
	Binding	CREB	Stimulatory	Feeding state	Gluconeogenesis↑	[23]
Liver fibrosis	Binding	NF-κB	Stimulatory	High-fat diet	Proinflammatory response↑	[24]
	Binding	β-Catenin	Stimulatory	/	Liver fibrosis↑	[25]
	Acetylation	SMAD3	Stimulatory	High-fat high-carbohydrate	Liver fibrosis↑	[26]
	Binding	HIF-1α	Stimulatory	/	Liver fibrosis↑	[27]