LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating -Synuclein Expression

Figure 1

The expression levels of lincRNA-p21 was detected in PD model mice and cells, and effects of lincRNA-p21 on cell viability and apoptosis of PD cells were shown. (a, b) The expression levels of lincRNA-p21 were increased significantly in PD mice and MPP⁺-induced SH-SY5Y cells. (c) Knockdown or overexpression of lincRNA-p21 increased or suppressed cell viability obviously in SH-SY5Y cells treated with MPP⁺. (d) Knockdown or overexpression of lincRNA-p21 inhibited or increased the activity of caspase-3 (cell apoptosis) markedly in SH-SY5Y cells treated with MPP⁺. All data are shown as the mean ± SD (P < 0.01, P < 0.001); bar, SD.

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