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BioMed Research International

BioMed Research International / 2018 / Article / Fig 4

Research Article

LincRNA-p21 Inhibits Cell Viability and Promotes Cell Apoptosis in Parkinson’s Disease through Activating -Synuclein Expression

Figure 4

LincRNA-p21 and miR-1277-5p regulated -synuclein expression and effects of coexpressing lincRNA-p21 and miR-1277-5p mimics on cell viability and apoptosis were detected in SH-SY5Y cells treated with MPP+. (a, b) The luciferase activity was detected after cotransfection of lincRNA-p21 and miR-1277-5p mimics/inhibitor in α-synuclein group. (c, d) The expression of α-synuclein was measured after cotransfection of lincRNA-p21 and miR-1277-5p mimics/inhibitor. (e) Cell viability was measured after cotransfection of lincRNA-p21 and miR-1277-5p mimics in SH-SY5Y cells. (f) Cell apoptosis was observed after cotransfection of lincRNA-p21 and miR-1277-5p mimics in SH-SY5Y cells. All data are shown as the mean ± SD (P < 0.05, P < 0.01, P < 0.001); bar, SD.
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