Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity

Table 2

Univariate and multivariate analyses of factors affecting overall survival in patients with intrahepatic cholangiocarcinoma (iCCA).

Characteristics	Univariate		Multivariate
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Age (years)
<60	1 (reference)	0.925	n.d.	n.d.
≥60	0.978 (0.614–1.558)
Gender
Female	1 (reference)	0.119	n.d.	n.d.
Male	1.464 (0.907–2.363)
Lymph node metastasis
No	1 (reference)	<0.001	1 (reference)	0.001
Yes	2.746 (1.744–4.323)		2.407 (1.435–4.037)
Tumor number
Solitary	1 (reference)	0.006		NS
Multiple	1.856 (1.191–2.893)
Tumor size (cm)
≤5	1 (reference)	0.001		NS
>5	2.210 (1.364–3.581)
TNM stage
I	1 (reference)	<0.001	1 (reference)	0.002
II–IV	3.542 (1.983–6.328)		2.677 (1.418–5.053)
AFU (U/L)
<20.85	1 (reference)	0.023	1 (reference)	0.006
≥20.85	0.596 (0.381–0.932)		0.526 (0.331–0.834)
CA19-9 (U/mL)
<100	1 (reference)	<0.001	1 (reference)	<0.001
≥100	2.793 (1.786–4.368)		2.778 (1.748–4.412)
ALT (U/L)
≤40	1 (reference)	0.664	n.d.	n.d.
>40	1.117 (0.678–1.839)
AST (U/L)
≤45	1 (reference)	0.210	n.d.	n.d.
>45	0.608 (0.280–1.323)

CI: confidence interval; AST: aspartate transaminase; ALT: alanine aminotransferase; AFU: alpha-L-fucosidase; CA19-9: carbohydrate antigen 19-9; n.d.: not done; NS: no significance.