BioMed Research International / 2018 / Article / Tab 2

Research Article

Alpha-L-Fucosidase Serves as a Prognostic Indicator for Intrahepatic Cholangiocarcinoma and Inhibits Its Invasion Capacity

Table 2

Univariate and multivariate analyses of factors affecting overall survival in patients with intrahepatic cholangiocarcinoma (iCCA).

CharacteristicsUnivariateMultivariate
Hazard ratio (95% CI) valueHazard ratio (95% CI) value

Age (years)
 <601 (reference)0.925n.d.n.d.
 ≥600.978 (0.614–1.558)
Gender
 Female1 (reference)0.119n.d.n.d.
 Male1.464 (0.907–2.363)
Lymph node metastasis
 No1 (reference)<0.0011 (reference)0.001
 Yes2.746 (1.744–4.323)2.407 (1.435–4.037)
Tumor number
 Solitary1 (reference)0.006NS
 Multiple1.856 (1.191–2.893)
Tumor size (cm)
 ≤51 (reference)0.001NS
 >52.210 (1.364–3.581)
TNM stage
 I1 (reference)<0.0011 (reference)0.002
 II–IV3.542 (1.983–6.328)2.677 (1.418–5.053)
AFU (U/L)
 <20.851 (reference)0.0231 (reference)0.006
 ≥20.850.596 (0.381–0.932)0.526 (0.331–0.834)
CA19-9 (U/mL)
 <1001 (reference)<0.0011 (reference)<0.001
 ≥1002.793 (1.786–4.368)2.778 (1.748–4.412)
ALT (U/L)
 ≤401 (reference)0.664n.d.n.d.
 >401.117 (0.678–1.839)
AST (U/L)
 ≤451 (reference)0.210n.d.n.d.
 >450.608 (0.280–1.323)

CI: confidence interval; AST: aspartate transaminase; ALT: alanine aminotransferase; AFU: alpha-L-fucosidase; CA19-9: carbohydrate antigen 19-9; n.d.: not done; NS: no significance.

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