Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 5
The relationship between IL-16-rs859, CYP24A1-rs4809957, and FBN1-rs1042078 and lung cancer risk in males.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 278) | (N = 245) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 523) | rs859
(call rate 99.81%) | Codominant | A/A | 67 (24.1%) | 71 (29.1%) | 1.00 | 0.190 | 1.00 | 0.084 | | G/A | 137 (49.3%) | 123 (50.4%) | 0.85 (0.56-1.28) | 0.79 (0.49-1.28) | | G/G | 74 (26.6%) | 50 (20.5%) | 0.64 (0.39-1.04) | 0.53 (0.30-0.94) | | Dominant | A/A | 67 (24.1%) | 71 (29.1%) | 1.00 | 0.200 | 1.00 | 0.120 | | G/A-G/G | 211 (75.9%) | 173 (70.9%) | 0.77 (0.52-1.14) | 0.70 (0.44-1.10) | | Recessive | A/A-G/A | 204 (73.4%) | 194 (79.5%) | 1.00 | 0.100 | 1.00 | 0.045 | | G/G | 74 (26.6%) | 50 (20.5%) | 0.71 (0.47-1.07) | 0.62 (0.39-0.99) | | Log-additive | --- | --- | --- | 0.80 (0.63-1.02) | 0.073 | 0.73 (0.55-0.97) | 0.029 |
| CYP24A1
(N = 523) | rs4809957
(call rate 100%) | Codominant | G/G | 98 (35.2%) | 90 (36.7%) | 1.00 | 0.810 | 1.00 | 0.280 | | G/A | 136 (48.9%) | 121 (49.4%) | 0.97 (0.66-1.41) | 0.91 (0.59-1.41) | | A/A | 44 (15.8%) | 34 (13.9%) | 0.84 (0.49-1.43) | 0.61 (0.33-1.13) | | Dominant | G/G | 98 (35.2%) | 90 (36.7%) | 1.00 | 0.720 | 1.00 | 0.390 | | G/A-A/A | 180 (64.8%) | 155 (63.3%) | 0.94 (0.66-1.34) | 0.83 (0.55-1.26) | | Recessive | G/G-G/A | 234 (84.2%) | 211 (86.1%) | 1.00 | 0.530 | 1.00 | 0.120 | | A/A | 44 (15.8%) | 34 (13.9%) | 0.86 (0.53-1.39) | 0.64 (0.36-1.13) | | Log-additive | --- | --- | --- | 0.93 (0.72-1.20) | 0.570 | 0.81 (0.60-1.09) | 0.160 |
| FBN1
(N = 523) | rs1042078
(call rate 100%) | Codominant | A/A | 85 (30.6%) | 65 (26.5%) | 1.00 | 0.220 | 1.00 | 0.280 | | A/G | 138 (49.6%) | 140 (57.1%) | 1.33 (0.89-1.98) | 1.31 (0.83-2.08) | | G/G | 55 (19.8%) | 40 (16.3%) | 0.95 (0.57-1.60) | 0.90 (0.50-1.62) | | Dominant | A/A | 85 (30.6%) | 65 (26.5%) | 1.00 | 0.310 | 1.00 | 0.440 | | A/G-G/G | 193 (69.4%) | 180 (73.5%) | 1.22 (0.83-1.79) | 1.19 (0.77-1.85) | | Recessive | A/A-A/G | 223 (80.2%) | 205 (83.7%) | 1.00 | 0.300 | 1.00 | 0.270 | | G/G | 55 (19.8%) | 40 (16.3%) | 0.79 (0.50-1.24) | 0.75 (0.45-1.25) | | Log-additive | --- | --- | --- | 1.01 (0.79-1.31) | 0.920 | 0.98 (0.73-1.31) | 0.900 |
|
|
SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, smoking status, and alcohol drinking status. Bold italics indicates the statistical significance ( P < 0.05). |
