Research Article
The Impact of IL-16 3′UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals
Table 8
The relationship between IL-16-rs859, CYP24A1-rs4809957,and FBN1-rs1042078 and lung cancer risk among nondrinkers.
| | Gene | SNP | Model | Genotype | Control | Case | Crude Analysis | Adjusted Analysis | | (N = 215) | (N = 229) | OR (95% CI) | P-value | OR (95% CI) | P-value |
| IL-16
(N = 444) | rs859
(call rate 99.77%) | Codominant | A/A | 47 (21.9%) | 62 (27.2%) | 1.00 | 0.200 | 1.00 | 0.110 | | G/A | 109 (50.7%) | 118 (51.8%) | 0.82 (0.52-1.30) | 0.78 (0.48-1.27) | | G/G | 59 (27.4%) | 48 (21.1%) | 0.62 (0.36-1.06) | 0.54 (0.31-0.96) | | Dominant | A/A | 47 (21.9%) | 62 (27.2%) | 1.00 | 0.190 | 1.00 | 0.130 | | G/A-G/G | 168 (78.1%) | 166 (72.8%) | 0.75 (0.48-1.16) | 0.70 (0.44-1.11) | | Recessive | A/A-G/A | 156 (72.6%) | 180 (79.0%) | 1.00 | 0.120 | 1.00 | 0.062 | | G/G | 59 (27.4%) | 48 (21.1%) | 0.71 (0.46-1.09) | 0.64 (0.40-1.03) | | Log-additive | --- | --- | --- | 0.80 (0.63-1.09) | 0.056 | 0.74 (0.55-0.98) | 0.036 |
| CYP24A1
(N = 444) | rs4809957
(call rate 100%) | Codominant | G/G | 78 (36.3%) | 89 (38.9%) | 1.00 | 0.650 | 1.00 | 0.550 | | G/A | 106 (49.3%) | 103 (45.0%) | 0.85 (0.57-1.28) | 0.79 (0.51-1.21) | | A/A | 31 (14.4%) | 37 (16.2%) | 1.05 (0.59-1.84) | 0.88 (0.48-1.61) | | Dominant | G/G | 78 (36.3%) | 89 (38.9%) | 1.00 | 0.570 | 1.00 | 0.300 | | G/A-A/A | 137 (63.7%) | 140 (61.1%) | 0.90 (0.61-1.32) | 0.81 (0.54-1.21) | | Recessive | G/G-G/A | 184 (85.6%) | 192 (83.8%) | 1.00 | 0.610 | 1.00 | 0.980 | | A/A | 31 (14.4%) | 37 (16.2%) | 1.14 (0.68-1.92) | 1.01 (0.58-1.75) | | Log-additive | --- | --- | --- | 0.98 (0.75-1.29) | 0.900 | 0.90 (0.68-1.20) | 0.480 |
| FBN1
(N = 444) | rs1042078
(call rate 100%) | Codominant | A/A | 63 (29.3%) | 61 (26.6%) | 1.00 | 0.058 | 1.00 | 0.210 | | A/G | 100 (46.5%) | 130 (56.8%) | 1.34 (0.87-2.08) | 1.18 (0.74-1.87) | | G/G | 52 (24.2%) | 38 (16.6%) | 0.75 (0.44-1.30) | 0.74 (0.42-1.32) | | Dominant | A/A | 63 (29.3%) | 61 (26.6%) | 1.00 | 0.530 | 1.00 | 0.880 | | A/G-G/G | 152 (70.7%) | 168 (73.4%) | 1.14 (0.75-1.73) | 1.04 (0.67-1.61) | | Recessive | A/A-A/G | 163 (75.8%) | 191 (83.4%) | 1.00 | 0.046 | 1.00 | 0.110 | | G/G | 52 (24.2%) | 38 (16.6%) | 0.62 (0.39-1.00) | 0.67 (0.41-1.09) | | Log-additive | --- | --- | --- | 0.90 (0.69-1.18) | 0.450 | 0.88 (0.66-1.18) | 0.400 |
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SNP: Single Nucleotide Polymorphism; OR: Odds Ratio; 95% CI: 95% Confidence Interval. P-value: P-values calculated by unconditional logistic regression analysis. P-value: P-values calculated by unconditional logistic regression analysis with adjustment for age, gender, and smoking status. Bold italics indicates the statistical significance ( P < 0.05). |
