Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients

Table 2

Moderate daily hypofractionation and weekly hypofractionation schedules in breast cancer.

(a) Daily hypofractionated schedules

Author	n	RDT schedule	Commentary
Shelley et al., 2000 [15]	294	40 Gy in 2.5 Gy/s, 22 days
Deutsch, 2002 [38]	47	Different schedules since; 50 Gy in 2 Gy to 36 Gy in 3 Gy	80–89 years old
Whelan et al., 2002 [39]	1234	Standard schedule 50 Gy in 2 Gy/s, 35 days, versus; hypofraction 42.5 Gy in 2.65 Gy/s, 22 days
Yarnold et al., 2005 [37]	1410	50 Gy in 2 Gy/s, 39 Gy in 3 Gy/s,; or; 42.9 Gy in 3.3 Gy/s
Haviland et al., 2013 [28]	2236	START A: 50 Gy in 2 Gy/s versus 41.6 Gy or 39 Gy in 13 s; START B: 50 Gy in 2 Gy/s versus 40 Gy in 15 s

(b) Weekly hypofractionated schedules

Author	n	RDT schedule	Commentary
Rostom et al., 1987 [21]	84	6.5 Gy × 6 s
Bates, 1988 [40]	411	3 Gy × 12 s (3 s/week = 28 days); versus; 6 Gy × 6 s (2 s/week = 18 days)	53 p biopsy, 13 p; lumpectomy, 18 p mastectomy
Baillet et al., 1990 [41]	230	45 Gy (1.8 Gy × 25 s in 33 days); versus; 23 Gy (5.75 Gy × 4 s in 17 days)
Maher et al., 1995 [23]	70	6.5 Gy × 5 s + boost 6.5 Gy × 2 s	Biopsy or cytology only
Ortholan et al., 2005 [22]	150	6.5 Gy × 5 s; supra 5.5 Gy × 5 s; boost 6.5 Gy × 1 or 2 s	108 p lumpectomy, 43 p mastectomy
Courdi et al., 2006 [24]	115	6.5 × 5 s	Median age 83 years, biopsy only
Sanz et al., 2008 [7]	262	6.25 Gy × 6 s (+6.25 Gy × 2 s if positive margin in conservative surgery)	22 p biopsy, 174 p lumpectomy, 66 p mastectomy
Dragun et al., 2011 [26]	42	6 Gy × 5 s	69% lumpectomy; 31% chemotherapy
Yarnold, 2011 [25]	915	50 Gy (2 Gy × 25 s) versus 28.5 Gy (5.7 × 5 s) or 30 Gy (6 Gy × 5 s)
Rovea et al., 2015 [27]	298	30 Gy (6 Gy × 5 s) or 32.5 Gy (6.5 Gy × 5 s)
Brunt et al., 2016 [35]	352	40 Gy in 15 s in 3 weeks versus 27 Gy in 5 s in 1 week or 26 Gy in 5 s in 1 week	Patients that require lymph node irradiation are excluded

RDT: radiation therapy; s: session; p: patient.