Effect of Astragalus Polysaccharides on Cardiac Dysfunction in db/db Mice with Respect to Oxidant Stress

Figure 4

Effects of APS on protein levels of apoptosis target genes in myocardium of db/db mice. Left ventricular tissues obtained from C57BJ/6J mice and db/db mice with or without APS treatment (n=6 per group) were prepared and subjected to Western blotting of apoptosis target genes. Membranes were stripped and reprobed for GAPDH as a loading control. Protein content was measured respectively and normalized as a ratio relative to the normal control. (a)~(c) Protein levels of Bax, Bcl-2, and caspase-3. (d) Representative autoradiographs of Western blots. Values were presented as mean ± standard error of the mean (SEM). P<0.05 versus C57BJ/6J control mice, and #P<0.05 versus db/db mice.

(a)

(b)

(c)

(d)